Effect of platelet-rich plasma on fracture healing

ABSTRACT Bone has the ability to completely regenerate under normal healing conditions. Although fractures generally heal uneventfully, problems such as delayed union or nonunion still occur in approximately 10% of patients. Optimal potential involves an interplay biomechanical and biological factors. Orthopedic implants are commonly used for providing necessary support. In situations where factors that needed fracture deemed inadequate, additional enhancement is needed. With platelets being packed with granules contain growth other proteins have osteoinductive capacity, local application platelet concentrates, also called platelet-rich plasma (PRP) seems attractive enhance healing. This review shows overview use PRP its effect enhancing extracted from patient's own blood, supporting considered safe. showed effective some studies, studies controversial results. Conflicts literature may be explained by absence consensus about preparation PRP, differences counts, low number patients, a standard technique. More addressing these issues order determine true on